PROSS: the Protein Repair One-Stop Shop
Designs summary
Read Troubleshooting 1 & 2 in our results help page for explanation about design warnings
Avoid design 9 unless the other designs are highly limited. details here
Designed sequences viewer
Mutated positions are easily recognized by having more than one letter in the sequence logo and more than one color per column
Mutation list per design
To sort by residue number, click on the position column. To sort by the number of designs in which mutations occur, click on the 1st column (#).
Alignment quality analysis
Read Troubleshooting 3 & 4 in our results help page for explanation about alignment quality messages
| Option | Value |
|---|---|
| Chain | A |
| PDB | 6vsb |
| name | viral Spike protein one subunit up (6vsb)) |
PROSS is free for academic users
Commercial users, please email info.yeda@weizmann.ac.il and fill our contact form
Questions and support
Overview & questions: contact us
Algorithm development
Adi Goldenzweig & Sarel Fleishman with a generous support from Jonathan Weinstein.
We thank Jaime Prilusky and Shi Hoch for developing the previous and new online interfaces.
Please cite:
Goldenzweig, A. et al. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Mol. Cell 2016, 63 (2), 337–346.
PMID: 27425410 PMCID: PMC4961223 PDF HTML
For more about the rationale behind PROSS and a list of other studies using PROSS checkout our About PROSS page.