PROSS: the Protein Repair One-Stop Shop

JobID: a4de301c-425d-493a-bc8c-a03770d93163
Created: April 4, 2020, 3:20 p.m. IST
Name: hACE2 no design on surface
Status: Complete

Designs summary

Read Troubleshooting 1 & 2 in our results help page for explanation about design warnings

view design1 view design2 view design3 view design4 view design5 view design6 view design7 view design8 view design9

Avoid design 9 unless the other designs are highly limited. details here

Designed sequences viewer

Mutated positions are easily recognized by having more than one letter in the sequence logo and more than one color per column

Mutation list per design

To sort by residue number, click on the position column. To sort by the number of designs in which mutations occur, click on the 1st column (#).

Alignment quality analysis

MSA quality

Read Troubleshooting 3 & 4 in our results help page for explanation about alignment quality messages

Option Value
Chain B
PDB 6m17
name hACE2 no design on surface

PROSS is free for academic users

Commercial users, please email info.yeda@weizmann.ac.il and fill our contact form

Questions and support
Overview & questions: contact us

Algorithm development
Adi Goldenzweig & Sarel Fleishman with a generous support from Jonathan Weinstein.
We thank Jaime Prilusky and Shi Hoch for developing the previous and new online interfaces.

Please cite:

Goldenzweig, A. et al. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Mol. Cell 2016, 63 (2), 337–346.
PMID: 27425410 PMCID: PMC4961223 PDF HTML

For more about the rationale behind PROSS and a list of other studies using PROSS checkout our About PROSS page.