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PROSS: the Protein Repair One-Stop Shop



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Pross Terms
Upload PDB?
Files
Structure info
AlphaFold2 confidence
Constraints
Upload MSA?
MSA file
PROSS MSA
Energy function
press [yes] only if using a model or an unpublished structure

NEW! a Hands-on tutorial for using the Fleishman lab protein-optimisation workflows.

Selected PROSS & FuncLib citations and patents (link).

PROSS is free for academic users

Commercial users, please email info.yeda@weizmann.ac.il and fill our contact form

Questions and support
Overview & questions: contact us

Algorithm development
Adi Goldenzweig & Sarel Fleishman with a generous support from Jonathan Weinstein.
We thank Jaime Prilusky and Shi Hoch for developing the previous and new online interfaces.

Please cite:

Goldenzweig, A. et al. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Mol. Cell 2016, 63 (2), 337–346.
PMID: 27425410 PMCID: PMC4961223 PDF HTML

For more about the rationale behind PROSS and a list of other studies using PROSS checkout our About PROSS page.