PROSS: the Protein Repair One-Stop Shop

Input

Pross Terms

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Files

Structure info

AlphaFold2 confidence

Constraints

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MSA file

MSA

Energy function

Email address*

Valid academic email address to send the reports to.

I undertake to use PROSS on behalf of my non-profit academic institute only. I, on behalf of my institute, accept the Terms and Conditions, whereby, without limitation, the results produced through such use, and any IP rights filed in respect of such results, shall be owned by the technology transfer office of the Weizmann Institute, and may be used by my institute for academic non-commercial purposes only. My institute may not commercialize such results, nor license or transfer such results to any third party for commercial purposes. Click on the question mark to read the Terms & Conditions.*

Examples FAQ About PROSS

NEW! a Hands-on tutorial for using the Fleishman lab protein-optimisation workflows.

Selected PROSS & FuncLib citations and patents (link).

PROSS is free for academic users

Commercial users, please email info.yeda@weizmann.ac.il and fill our contact form

Questions and support
Overview & questions: contact us

Algorithm development
Adi Goldenzweig & Sarel Fleishman with a generous support from Jonathan Weinstein.
We thank Jaime Prilusky and Shi Hoch for developing the previous and new online interfaces.

Please cite:

Goldenzweig, A. et al. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Mol. Cell 2016, 63 (2), 337–346.
PMID: 27425410 PMCID: PMC4961223 PDF HTML

For more about the rationale behind PROSS and a list of other studies using PROSS checkout our About PROSS page.